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The common side effects of retatrutide are: Nausea Vomiting Diarrhea Constipation Fatigue Abdominal discomfort Early satiety Injection site reactions Increased heart rate Serious side effects of the medication include the following: Allergic or hypersensitivity reaction Liver problems Severe gastrointestinal issues Major depressive disorder Suicidal ideal Changes in mood and behavior Pancreatitis Low blood sugar levels (hypoglycemia) Cardiac arrhythmias The drug is still not FDA-approved and contraindications have not yet been determined